Around 5 million people worldwide live with lupus, a chronic disease that causes the body’s immune system to attack healthy tissue. Sufferers are typical afflicted by symptoms like joint stiffness, hair loss, fatigue and photosensitivity. Untreated, lupus can be fatal as it can cause healthy organs to fail. And although immunosuppressant drugs have proven to be an effective treatment for the malady, there is no cure for lupus. While less prevalent than some autoimmune diseases, lupus has touched the lives of many celebrities, most recently Selena Gomez, who revealed that she has the disorder in an Oct. 7. Interview with Billboard magazine. Here are 12 stars who have struggled with lupus.